An important factor of note is that PDF infections are usually through the JavaScript backend. The JavaScript back end is, to my knowledge, only supported by the official Acrobat clients, either with full Acrobat, or Adobe Reader. If you are a home or small office user, disabling JavaScript functionality in your Adobe Acrobat or Reader client will help prevent accidental infection. If you are in an enterprise environment and either do deploy Adobe Reader or are looking to, Adobe provides tools to create Windows MSI installer packages with options preconfigured, including but not limited to